Globular changes in cytomegaloviral inclusions after Ganciclovir treatment

Arch Virol. 1989;108(3-4):287-93. doi: 10.1007/BF01310941.

Abstract

Ganciclovir treatment induced eosinophilic intranuclear globules and loss of DNA staining in pulmonary CMV-infected cells. Nuclear capsids contained ring-shaped cores. Cytoplasmic vacuoles contained altered, enveloped, mostly coreless viral particles.

Publication types

  • Case Reports

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications
  • Adult
  • Bone Marrow Transplantation
  • Capsid / ultrastructure
  • Cytomegalovirus / drug effects*
  • Cytomegalovirus / ultrastructure
  • Cytomegalovirus Infections / complications
  • Cytomegalovirus Infections / drug therapy*
  • Cytomegalovirus Infections / etiology
  • Cytomegalovirus Infections / pathology
  • DNA, Viral / biosynthesis
  • DNA, Viral / drug effects
  • Eosine Yellowish-(YS)
  • Female
  • Ganciclovir / therapeutic use*
  • Humans
  • Kidney Transplantation
  • Lung / microbiology
  • Lung / ultrastructure*
  • Male
  • Pneumonia / drug therapy
  • Pneumonia / etiology
  • Postoperative Complications / drug therapy
  • Postoperative Complications / microbiology

Substances

  • DNA, Viral
  • Ganciclovir
  • Eosine Yellowish-(YS)