GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China

Yi Zeng; Huashuai Chen; Ting Ni; Rongping Ruan; Lei Feng; Chao Nie; Lingguo Cheng; Yang Li; Wei Tao; Jun Gu; Kenneth C Land; Anatoli Yashin; Qihua Tan; Ze Yang; Lars Bolund; Huanming Yang; Elizabeth Hauser; D Craig Willcox; Bradley J Willcox; Xiao-Li Tian; James W Vaupel

doi:10.1093/gerona/glu060

GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China

J Gerontol A Biol Sci Med Sci. 2015 Apr;70(4):426-33. doi: 10.1093/gerona/glu060. Epub 2014 Jun 3.

Authors

Yi Zeng¹, Huashuai Chen², Ting Ni³, Rongping Ruan⁴, Lei Feng⁵, Chao Nie⁶, Lingguo Cheng⁷, Yang Li⁸, Wei Tao⁹, Jun Gu⁹, Kenneth C Land¹⁰, Anatoli Yashin¹⁰, Qihua Tan¹¹, Ze Yang¹², Lars Bolund¹³, Huanming Yang¹⁴, Elizabeth Hauser¹⁵, D Craig Willcox¹⁶, Bradley J Willcox¹⁷, Xiao-Li Tian⁸, James W Vaupel¹⁸

Affiliations

¹ Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, North Carolina. Center for Healthy Aging and Development Studies, National School of Development, Peking University, Beijing, China.
² Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, North Carolina. Business School of Xiangtan University, Hunan, China.
³ State Key Laboratory of Genetics Engineering & MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
⁴ Renmin University of China, Beijing, China.
⁵ National University of Singapore.
⁶ BGI-Shenzhen, China.
⁷ School of Business, Nanjing University, China.
⁸ Department of Human Population Genetics, Institute of Molecular Medicine, Peking University, Beijing, China.
⁹ School of Life Sciences, Peking University, Beijing, China.
¹⁰ Population Research Institute, Duke University, Durham, North Carolina.
¹¹ Unit of Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense.
¹² National Institute of Geriatrics, Beijing Hospital, Ministry of Health of China, Beijing, China.
¹³ BGI-Shenzhen, China. Department of Biomedicine, Aarhus University, Denmark.
¹⁴ BGI-Shenzhen, China. James D. Watson Institute of Genome Sciences, Hangzhou, China. Princess Al-Jawhara Centre of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
¹⁵ Center for Human Genetics, Medical Center, Duke University, Durham, North Carolina.
¹⁶ Department of Human Welfare, Okinawa International University, Ginowan, Japan. Department of Research, Kuakini Medical Center and Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu.
¹⁷ Department of Research, Kuakini Medical Center and Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu.
¹⁸ Max Planck Institute for Demographic Research, Rostock, Germany.

Abstract

Logistic regression analysis based on data from 822 Han Chinese oldest old aged 92+ demonstrated that interactions between carrying FOXO1A-266 or FOXO3-310 or FOXO3-292 and tea drinking at around age 60 or at present time were significantly associated with lower risk of cognitive disability at advanced ages. Associations between tea drinking and reduced cognitive disability were much stronger among carriers of the genotypes of FOXO1A-266 or FOXO3-310 or FOXO3-292 compared with noncarriers, and it was reconfirmed by analysis of three-way interactions across FOXO genotypes, tea drinking at around age 60, and at present time. Based on prior findings from animal and human cell models, we postulate that intake of tea compounds may activate FOXO gene expression, which in turn may positively affect cognitive function in the oldest old population. Our empirical findings imply that the health benefits of particular nutritional interventions, including tea drinking, may, in part, depend upon individual genetic profiles.

Keywords: Cognitive disability; FOXO genotypes; GxE interactions; Oldest old.; Tea drinking.

Publication types

Comparative Study
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aged, 80 and over
Aging / genetics*
Alleles
Asian People / genetics*
China / ethnology
Cognition / drug effects*
Cognition Disorders / ethnology
Cognition Disorders / genetics
Cognition Disorders / prevention & control*
Drinking Behavior*
Evidence-Based Medicine
Female
Forkhead Box Protein O1
Forkhead Box Protein O3
Forkhead Transcription Factors / genetics*
Gene Expression
Genotype
Humans
Longitudinal Studies
Male
Phenotype
Risk Factors
Surveys and Questionnaires
Tea*

Substances

FOXO1 protein, human
FOXO3 protein, human
Forkhead Box Protein O1
Forkhead Box Protein O3
Forkhead Transcription Factors
Tea

Abstract

Publication types

MeSH terms

Substances

Grants and funding