Patients benefit from genetics-guided coumarin anticoagulant therapy

Clin Pharmacol Ther. 2014 Jul;96(1):15-7. doi: 10.1038/clpt.2014.44.

Abstract

Observational studies have overwhelmingly shown that variants in the genes CYP2C9 and VKORC1 are significant determinants of individual dose of coumarin anticoagulants needed to maintain a therapeutic international normalized ratio (INR).(1) Until recently, however, few randomized clinical trials had been performed relating to the use of genetic data to predict dosing. Three sucsh clinical trials have now reported their findings.

Publication types

  • Comment

MeSH terms

  • Acenocoumarol / administration & dosage*
  • Acenocoumarol / pharmacokinetics*
  • Algorithms*
  • Anticoagulants / administration & dosage*
  • Anticoagulants / pharmacokinetics*
  • Aryl Hydrocarbon Hydroxylases / genetics*
  • Blood Coagulation / drug effects*
  • Female
  • Genotype*
  • Humans
  • Male
  • Mixed Function Oxygenases / genetics*
  • Phenprocoumon / administration & dosage*
  • Vitamin K Epoxide Reductases / genetics*
  • Warfarin / administration & dosage*

Substances

  • Anticoagulants
  • Warfarin
  • Mixed Function Oxygenases
  • Aryl Hydrocarbon Hydroxylases
  • Vitamin K Epoxide Reductases
  • Acenocoumarol
  • Phenprocoumon