Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations

PLoS One. 2014 Jun 19;9(6):e100055. doi: 10.1371/journal.pone.0100055. eCollection 2014.

Abstract

MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1, rs895819/pre-miR-27a, and rs11134527/pri-miR-218 were reported to be associated with risks of various cancers. In order to evaluate the relationship of these SNPs and esophageal squamous cell carcinoma (ESCC) risk, we conducted a case-control study with 1109 ESCC patients and 1275 control subjects to examine the potential association of these pri/pre-miRNA polymorphisms with ESCC susceptibility. As a result, two SNPs were associated with a significant risk of ESCC. We found that the GG genotype of pri-miR-124-1 rs531564 was associated to a significantly decreased risk of ESCC comparing with the CC/CG genotypes (p = 0.005; OR = 0.61, 95% CI = 0.43-0.86). In addition, the CC genotype of pri-miR-34b/c rs4938723 was associated with a significant decreased risk of ESCC (CC VS.

Tt/tc: p = 0.007, OR = 0.82, 95% CI = 0.71-0.95) in Chinese population. The present study provides the first evidence that pri-miR-124-1 rs531564 and pri-miR-34 rs4938723 were associated with the risk of ESCC in Chinese population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alcohol Drinking / genetics
  • Asian People / genetics*
  • Carcinoma, Squamous Cell / genetics*
  • Case-Control Studies
  • China
  • Esophageal Neoplasms / genetics*
  • Esophageal Squamous Cell Carcinoma
  • Female
  • Genetic Association Studies*
  • Genetic Predisposition to Disease*
  • Humans
  • Male
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Middle Aged
  • Multifactor Dimensionality Reduction
  • Polymorphism, Single Nucleotide / genetics*
  • Risk Factors
  • Smoking / genetics

Substances

  • MIRN124 microRNA, human
  • MIRN34 microRNA, human
  • MicroRNAs

Grants and funding

This work was supported by the grant from the National Natural Science Foundation fo China (grant number 81071957)(http://www.nsfc.gov.cn/), the Ministry of Health (grant number 201002007)(http://www.nhfpc.gov.cn/qjjys/index.shtml), the Key Project in the National Science & Techonlogy Pillar Program (grant number 2011BAI09B00)(http://kjzc.jhgl.org/), and the funds from “China’s Thousand Talents Program” at Fudan University (http://www.1000plan.org/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.