Clinical course of recurrent respiratory papillomatosis: comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11

Robin E A Tjon Pian Gi; Michel R M San Giorgi; Lorian Slagter-Menkema; Bettien M van Hemel; Bernard F A M van der Laan; Edwin R van den Heuvel; Frederik G Dikkers; Ed M D Schuuring

doi:10.1002/hed.23808

Clinical course of recurrent respiratory papillomatosis: comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11

Head Neck. 2015 Nov;37(11):1625-32. doi: 10.1002/hed.23808. Epub 2014 Sep 12.

Authors

Robin E A Tjon Pian Gi^{1

2}, Michel R M San Giorgi^{1

2}, Lorian Slagter-Menkema^{1

3

2}, Bettien M van Hemel^{3

2}, Bernard F A M van der Laan^{1

2}, Edwin R van den Heuvel^{4

2}, Frederik G Dikkers^{1

2}, Ed M D Schuuring^{3

2}

Affiliations

¹ Department of Otorhinolaryngology/Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
² Graduate School of Medical Sciences (Groningen University Institute for Drug Exploration), University of Groningen, The Netherlands.
³ Department of Pathology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
⁴ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

PMID: 24955561
DOI: 10.1002/hed.23808

Abstract

Background: Recurrent respiratory papillomatosis (RRP) is mainly associated with human papillomavirus (HPV)6 or HPV11. The purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between HPV6- and HPV11-associated RRP.

Methods: A retrospective cohort of 55 patients with RRP (1974-2012) was used. Surgical interventions (n = 814) were analyzed, and complications scored. HPV6/11-specific polymerase chain reaction (PCR) was performed on RRP biopsies.

Results: Seventy-six percent of patients (42 of 55) were infected with HPV6 and 24% (13 of 55) with HPV11. The HPV11 group had anatomically more widespread disease. The expected number of surgical interventions was higher in the younger age (<22.4 years) HPV11 group, and the older age (<22.4 years) HPV6 group. Regardless of HPV type, earlier age of onset of RRP resulted in a higher number of surgical interventions.

Conclusion: Anatomically, HPV11-associated RRP behaves more aggressively. Younger patients with HPV11 and older patients with HPV6 experience a worse clinical course of RRP.

Keywords: HPV; HPV11; clinical course; human papillomavirus, HPV6; recurrent respiratory papillomatosis.

MeSH terms

Adult
Age Distribution
Biopsy, Needle
Cohort Studies
Female
Hospitals, University
Human papillomavirus 11 / isolation & purification*
Human papillomavirus 6 / isolation & purification*
Humans
Immunohistochemistry
Incidence
Male
Netherlands
Papillomavirus Infections / epidemiology
Papillomavirus Infections / pathology*
Papillomavirus Infections / surgery
Papillomavirus Infections / virology*
Polymerase Chain Reaction / methods
Prognosis
Respiratory Tract Infections / epidemiology
Respiratory Tract Infections / pathology*
Respiratory Tract Infections / surgery
Respiratory Tract Infections / virology*
Retrospective Studies
Risk Assessment
Severity of Illness Index
Sex Distribution
Young Adult

Supplementary concepts

Recurrent respiratory papillomatosis