Abstract
We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei after inoculation and systemic spread.
Copyright © 2014 Limmathurotsakul et al.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Burkholderia pseudomallei / classification*
-
Burkholderia pseudomallei / genetics*
-
Burkholderia pseudomallei / isolation & purification
-
DNA, Bacterial / chemistry
-
DNA, Bacterial / genetics
-
Evolution, Molecular*
-
Genetic Variation*
-
Genome, Bacterial
-
Genotype
-
Humans
-
Male
-
Melioidosis / microbiology*
-
Molecular Sequence Data
-
Sequence Analysis, DNA
-
Young Adult
Associated data
-
GENBANK/LK936442
-
GENBANK/LK936443