Microevolution of Burkholderia pseudomallei during an acute infection

J Clin Microbiol. 2014 Sep;52(9):3418-21. doi: 10.1128/JCM.01219-14. Epub 2014 Jun 25.

Abstract

We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei after inoculation and systemic spread.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Burkholderia pseudomallei / classification*
  • Burkholderia pseudomallei / genetics*
  • Burkholderia pseudomallei / isolation & purification
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Evolution, Molecular*
  • Genetic Variation*
  • Genome, Bacterial
  • Genotype
  • Humans
  • Male
  • Melioidosis / microbiology*
  • Molecular Sequence Data
  • Sequence Analysis, DNA
  • Young Adult

Substances

  • DNA, Bacterial

Associated data

  • GENBANK/LK936442
  • GENBANK/LK936443