Prediction of human clearance (CL) and volume of distribution (VD)

Jörg Keldenich

doi:10.1016/j.ddtec.2004.10.007

Prediction of human clearance (CL) and volume of distribution (VD)

Drug Discov Today Technol. 2004 Dec;1(4):389-95. doi: 10.1016/j.ddtec.2004.10.007.

Author

Jörg Keldenich¹

Affiliation

¹ Bayer HealthCare AG, Pharmaceutical Research, D-42096 Wuppertal, Germany. Electronic address:joerg.keldenich@bayerhealthcare.com.

PMID: 24981619
DOI: 10.1016/j.ddtec.2004.10.007

Abstract

The crucial pharmacokinetic parameters 'volume of distribution' and 'human clearance' determine the extent and duration a compound remains in an organism. Potential drug candidates will fail to become successful drugs on the market without favorable values for these parameters, even if they are most efficacious at the target in vitro.The prediction of volume of distribution and human clearance in drug research and development is a key technology to assess possible drug candidates.: