LRRK2 parkinsonism in Tunisia and Norway: a comparative analysis of disease penetrance

Neurology. 2014 Aug 5;83(6):568-9. doi: 10.1212/WNL.0000000000000675. Epub 2014 Jul 9.

Abstract

In recent years, the molecular etiology of parkinsonism has yielded to genetic analysis.1 Mutations in the gene leucine-rich repeat kinase 2 (LRRK2) have the highest genotypic and population attributable risk. Disparate penetrance estimates have been reported using a variety of statistical analyses, ethnic populations, and sample sizes.2 We compared the age-associated cumulative incidence (penetrance) of LRRK2 p.G2019S patients from Tunisia and Norway.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Female
  • Humans
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Male
  • Middle Aged
  • Norway / ethnology
  • Parkinsonian Disorders / diagnosis
  • Parkinsonian Disorders / ethnology*
  • Parkinsonian Disorders / genetics*
  • Penetrance*
  • Protein Serine-Threonine Kinases / genetics*
  • Tunisia / ethnology
  • Young Adult

Substances

  • LRRK2 protein, human
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Protein Serine-Threonine Kinases