A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines

Chem Commun (Camb). 2014 Sep 14;50(71):10222-4. doi: 10.1039/c4cc04940c.

Abstract

Rh-catalysed conjugate additions of 2-aminophenyl boronic acid derivatives were exploited in diastereoselective and asymmetric syntheses of tetrahydroquinolines. In both cases, combinatorial variation of the substitution of the tetrahydroquinoline ring system was possible.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Chemistry Techniques, Synthetic / methods*
  • Quinolines / chemical synthesis*
  • Rhodium / chemistry*
  • Rhodium / metabolism*
  • Stereoisomerism

Substances

  • Quinolines
  • 1,2,3,4-tetrahydroquinoline
  • Rhodium