Mantle cell lymphoma with features of marginal-zone lymphoma

Ulla Randen; Olav Erich Yri; Anne Tierens; Sverre Heim; Klaus Beiske; Jan Delabie

doi:10.1007/s12308-011-0084-x

Mantle cell lymphoma with features of marginal-zone lymphoma

J Hematop. 2011 Mar 2;4(1):7-11. doi: 10.1007/s12308-011-0084-x. eCollection 2011 Mar.

Authors

Ulla Randen¹, Olav Erich Yri², Anne Tierens¹, Sverre Heim³, Klaus Beiske⁴, Jan Delabie¹

Affiliations

¹ Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway.
² Department of Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
³ Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital and University of Oslo, Oslo, Norway.
⁴ Department of Pathology, The National Hospital, Oslo University Hospital, Oslo, Norway.

Abstract

We present seven cases of mantle cell lymphoma with morphological features of marginal-zone lymphoma. Of particular interest, four of the patients had predominant involvement of the gastrointestinal tract. All cases displayed the translocation t(11;14)(q13;q32) and expressed cyclin D1. Cytogenetic analysis revealed trisomy 3 in one case and somatic hypermutation of immunoglobulin heavy genes could be demonstrated in two out of four cases. The latter features are reminiscent of marginal-zone lymphoma. The localization of these lymphomas mainly in the gastrointestinal tract and the higher exposure to antigens in this area may explain why this variant of mantle cell lymphoma harbours features of marginal-zone lymphoma.

Keywords: Cyclin D1; GI tract; Mantle cell lymphoma; Marginal-zone lymphoma.