Risk factors for preterm premature rupture of membranes in Chinese women from urban cities

Qiongjie Zhou; Weiyuan Zhang; Huan Xu; Huan Liang; Yan Ruan; Shufeng Zhou; Xiaotian Li

doi:10.1016/j.ijgo.2014.06.020

Risk factors for preterm premature rupture of membranes in Chinese women from urban cities

Int J Gynaecol Obstet. 2014 Dec;127(3):254-9. doi: 10.1016/j.ijgo.2014.06.020. Epub 2014 Aug 13.

Authors

Qiongjie Zhou¹, Weiyuan Zhang², Huan Xu¹, Huan Liang¹, Yan Ruan², Shufeng Zhou³, Xiaotian Li⁴

Affiliations

¹ Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China; The Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China.
² Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
³ Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA.
⁴ Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China; The Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China; Institute of Biomedical Sciences, Fudan University, Shanghai, China. Electronic address: xiaotianli555@163.com.

PMID: 25200254
DOI: 10.1016/j.ijgo.2014.06.020

Abstract

Objective: To investigate the prevalence of preterm premature rupture of membranes (PPROM) in urban areas in China and examine the associated risk factors.

Methods: A population-based, prospective study was undertaken in 14 cities in China between January 1, 2011, and January 31, 2012. Women were recruited at their first prenatal-care visit, when maternal characteristics were recorded. Risk factors were analyzed by one-way analysis of variance.

Results: Of 112 439 women included in analyses, 3077 (2.7%) had PPROM. Univariate analysis showed an increased risk of PPROM before 28weeks of pregnancy in migrant women (odds ratio [OR] 2.25; 95% confidence interval [CI] 1.53-3.30; P<0.001), in those with a history of recurrent induced abortions (OR 2.75; 95% CI 1.66-4.56; P<0.001), and in those with a history of preterm birth (OR 3.90; 95% CI 0.77-19.61; P<0.001). The associations were maintained in multivariate analysis (P<0.001).

Conclusion: Migration as a result of urbanization, high rates of induced abortion, and preterm birth are potential risk factors for PPROM in Chinese women.

Keywords: Chinese people; Epidemiology; Induced abortion; Migrants; Preterm premature rupture of membranes (PPROM); Urbanization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abortion, Induced / adverse effects
Adult
Analysis of Variance
China / epidemiology
Cities / epidemiology
Female
Fetal Membranes, Premature Rupture / epidemiology*
Fetal Membranes, Premature Rupture / etiology*
Gestational Age
Humans
Pregnancy
Premature Birth / epidemiology
Prevalence
Prospective Studies
Risk Factors
Transients and Migrants / statistics & numerical data
Urban Population / statistics & numerical data*

Supplementary concepts

Preterm Premature Rupture of the Membranes