GIANT: a cytoscape plugin for modular networks

PLoS One. 2014 Oct 2;9(9):e105001. doi: 10.1371/journal.pone.0105001. eCollection 2014.

Abstract

Network analysis provides deep insight into real complex systems. Revealing the link between topological and functional role of network elements can be crucial to understand the mechanisms underlying the system. Here we propose a Cytoscape plugin (GIANT) to perform network clustering and characterize nodes at the light of a modified Guimerà-Amaral cartography. This approach results into a vivid picture of the a topological/functional relationship at both local and global level. The plugin has been already approved and uploaded on the Cytoscape APP store.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Gene Expression Regulation, Plant
  • Gene Regulatory Networks*
  • Hemoglobins / chemistry
  • Humans
  • Software*
  • Vitis / genetics

Substances

  • Hemoglobins

Grants and funding

The manuscript has been produced thanks to the financial support from SysBioNet, Italian Roadmap Research Infrastructures 2012 and from The Epigenomics Flagship Project (Progetto Bandiera Epigenomica) EPIGEN funded by Italian Ministry of Education, University and Research (MIUR) and the National Research Council of Italy (CNR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.