Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology

Br J Haematol. 2015 Feb;168(4):547-52. doi: 10.1111/bjh.13162. Epub 2014 Oct 7.

Abstract

We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5 years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.

Keywords: acute leukaemia; cerebral sinovenous thrombosis; paediatric.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / adverse effects
  • Anticoagulants / adverse effects
  • Anticoagulants / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Asparaginase / administration & dosage
  • Asparaginase / adverse effects
  • Baltic States / epidemiology
  • Child
  • Child, Preschool
  • Consolidation Chemotherapy
  • Female
  • Humans
  • Incidence
  • Infant
  • Male
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Prospective Studies
  • Risk Factors
  • Scandinavian and Nordic Countries / epidemiology
  • Sinus Thrombosis, Intracranial / drug therapy
  • Sinus Thrombosis, Intracranial / epidemiology
  • Sinus Thrombosis, Intracranial / etiology*
  • Treatment Outcome

Substances

  • Adrenal Cortex Hormones
  • Anticoagulants
  • Asparaginase