In white rats with experimental ulcer of the stomach, a single session of acupuncture (AP) considerably increased the contents of beta-endorphine (ED) and adrenaline (A) in the hypothalamus. Repeated AP sessions aided to a progressive decrease in the ED, A and noradrenaline (NA) levels. The AP did not change essentially the dynamics of ED, A and NA by itself. The ulcer pathology against the background of AP sessions is accompanied by a change in activity of hypothalamic systems of the ED, A and NA, and by a formation of a specific neurochemical profile changing in time.