Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823

J Antibiot (Tokyo). 2015 May;68(5):342-4. doi: 10.1038/ja.2014.147. Epub 2014 Oct 22.

Authors

Shotaro Hoshino¹, Lihan Zhang¹, Takayoshi Awakawa¹, Toshiyuki Wakimoto¹, Hiroyasu Onaka², Ikuro Abe¹

Affiliations

¹ Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
² Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

PMID: 25335694
DOI: 10.1038/ja.2014.147

No abstract available

MeSH terms

Actinobacteria / metabolism*
Alkaloids / chemistry*
Alkaloids / metabolism
Alkaloids / pharmacology*
Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / metabolism
Antineoplastic Agents / pharmacology*
Carbazoles / chemistry*
Carbazoles / metabolism
Carbazoles / pharmacology*
Cell Line, Tumor
Coculture Techniques
Leukemia P388 / drug therapy
Mice
Streptomyces / chemistry
Streptomyces / metabolism*

Substances

Alkaloids
Antineoplastic Agents
Carbazoles
arcyriaflavin A
arcyriaflavin E
BE 13793C