Abstract
Background and methods:
A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety.
Results and conclusions:
Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adenine / analogs & derivatives*
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Adenine / pharmacokinetics
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Adenine / pharmacology
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Administration, Intravaginal
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Animals
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Anti-HIV Agents / pharmacokinetics*
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Drug Delivery Systems
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Female
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HIV / drug effects*
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Lentivirus Infections / prevention & control*
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Macaca nemestrina*
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Organophosphonates / administration & dosage
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Organophosphonates / pharmacokinetics
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Organophosphonates / pharmacology*
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Simian Immunodeficiency Virus / drug effects*
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Tenofovir
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Time Factors
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Vagina / metabolism
Substances
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Anti-HIV Agents
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Organophosphonates
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Tenofovir
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Adenine