Genomic dissection of travel-associated extended-spectrum-beta-lactamase-producing Salmonella enterica serovar typhi isolates originating from the Philippines: a one-off occurrence or a threat to effective treatment of typhoid fever?

Rene S Hendriksen; Pimlapas Leekitcharoenphon; Matthew Mikoleit; Jacob Dyring Jensen; Rolf Sommer Kaas; Louise Roer; Heena B Joshi; Srirat Pornruangmong; Chaiwat Pulsrikarn; Gladys D Gonzalez-Aviles; E Ascelijn Reuland; Nashwan Al Naiemi; Astrid Louise Wester; Frank M Aarestrup; Henrik Hasman

doi:10.1128/JCM.03104-14

Genomic dissection of travel-associated extended-spectrum-beta-lactamase-producing Salmonella enterica serovar typhi isolates originating from the Philippines: a one-off occurrence or a threat to effective treatment of typhoid fever?

J Clin Microbiol. 2015 Feb;53(2):677-80. doi: 10.1128/JCM.03104-14. Epub 2014 Nov 26.

Authors

Rene S Hendriksen¹, Pimlapas Leekitcharoenphon², Matthew Mikoleit³, Jacob Dyring Jensen², Rolf Sommer Kaas², Louise Roer², Heena B Joshi³, Srirat Pornruangmong⁴, Chaiwat Pulsrikarn⁴, Gladys D Gonzalez-Aviles³, E Ascelijn Reuland⁵, Nashwan Al Naiemi⁶, Astrid Louise Wester⁷, Frank M Aarestrup², Henrik Hasman²

Affiliations

¹ Technical University of Denmark, National Food Institute, WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Kongens Lyngby, Denmark rshe@food.dtu.dk.
² Technical University of Denmark, National Food Institute, WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Kongens Lyngby, Denmark.
³ Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of Foodborne, Waterborne, and Environmental Diseases, Enteric Diseases Laboratory Branch, Atlanta, Georgia, USA.
⁴ National Institute of Health, Department of Medical Sciences, WHO National Salmonella and Shigella Center, Ministry of Public Health, Bangkok, Thailand.
⁵ Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, the Netherlands.
⁶ Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, the Netherlands Ziekenhuis Groep Twente, Amsterdam, the Netherlands.
⁷ Norwegian Institute of Public Health, Division of Infectious Disease Control, Department of Foodborne Infections, Oslo, Norway.

Abstract

One unreported case of extended-spectrum-beta-lactamase (ESBL)-producing Salmonella enterica serovar Typhi was identified, whole-genome sequence typed, among other analyses, and compared to other available genomes of S. Typhi. The reported strain was similar to a previously published strain harboring blaSHV-12 from the Philippines and likely part of an undetected outbreak, the first of ESBL-producing S. Typhi.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Disease Outbreaks
Genome, Bacterial
Genotype
Humans
Molecular Sequence Data
Philippines / epidemiology
Salmonella typhi / enzymology*
Salmonella typhi / genetics
Salmonella typhi / isolation & purification*
Sequence Analysis, DNA
Travel*
Typhoid Fever / epidemiology
Typhoid Fever / microbiology*
beta-Lactamases / genetics
beta-Lactamases / metabolism*

Substances

beta-Lactamases

Associated data

SRA/ERS525820
SRA/ERS525821