The SRI domain is a small three-helix domain originally discovered near the C-terminus of both histone methyltransferase SETD2 and helicase RECQL5. The SRI domain binds to the C-terminal repeat domain of the largest subunit of RNA polymerase II, allowing SETD2 and RECQL5 to regulate various mechanisms associated with RNA transcription. Using original tools to detect common patterns in distantly related sequences, we have identified SRI domains in several additional proteins, most of which are involved in RNA metabolism. Combining sequence analysis with structural prediction, we show that this domain family is more diverse than previously thought and we predict critical structural and functional features.
Keywords: FRIGIDA-ESSENTIAL 1; LSD1-like homolog 3; PHRF1; SCAF1; SCAF11; Sequence analysis.
Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.