Dipeptide repeat protein toxicity in frontotemporal lobar degeneration and in motor neurone disease associated with expansions in C9ORF72-a cautionary note

Neurobiol Aging. 2015 Feb;36(2):1224-6. doi: 10.1016/j.neurobiolaging.2014.10.011. Epub 2014 Oct 16.

Author

David M A Mann¹

Affiliation

¹ Clinical and Cognitive Neuroscience Research Group, Institute of Brain Behaviour and Mental Health, University of Manchester, Salford Royal Hospital, Salford, UK. Electronic address: david.mann@manchester.ac.uk.

PMID: 25457023
DOI: 10.1016/j.neurobiolaging.2014.10.011

No abstract available

Publication types

Letter

MeSH terms

Aged
Aged, 80 and over
Animals
C9orf72 Protein
DNA Repeat Expansion / genetics*
DNA-Binding Proteins
Dipeptides / metabolism*
Dipeptides / toxicity*
Disease Models, Animal
Drosophila
Frontotemporal Lobar Degeneration / genetics*
Humans
Motor Neuron Disease / genetics*
Proteins / genetics*

Substances

C9orf72 Protein
C9orf72 protein, human
DNA-Binding Proteins
Dipeptides
Proteins
TARDBP protein, human