Innate immunity and epigenetic plasticity in cellular reprogramming

John P Cooke; Nazish Sayed; Jieun Lee; Wing Tak Wong

doi:10.1016/j.gde.2014.11.002

Innate immunity and epigenetic plasticity in cellular reprogramming

Curr Opin Genet Dev. 2014 Oct:28:89-91. doi: 10.1016/j.gde.2014.11.002.

Authors

John P Cooke¹, Nazish Sayed², Jieun Lee³, Wing Tak Wong²

Affiliations

¹ Center for Cardiovascular Regeneration, Houston Methodist Research Institute, United States. Electronic address: jpcooke@houstonmethodist.org.
² Center for Cardiovascular Regeneration, Houston Methodist Research Institute, United States.
³ Department of Medicine, Stanford University, United States.

Abstract

Somatic cells can be reprogrammed to express the features of pluripotent cells, in that they can be differentiated into all three germ layers, and that they have the ability to replicate indefinitely. Recent studies suggest that the efficient induction of pluripotency requires the activation of innate immunity.

Publication types

Review

MeSH terms

Animals
Cellular Reprogramming / immunology*
Epigenesis, Genetic*
Humans
Immunity, Innate*
Pluripotent Stem Cells / cytology*
Pluripotent Stem Cells / immunology*
Pluripotent Stem Cells / metabolism

Grants and funding

U01 HL100397/HL/NHLBI NIH HHS/United States