Recent Advances in Asymmetric Catalytic Methods for the Formation of Acyclic α,α-Disubstituted α-Amino Acids

Alison E Metz; Marisa C Kozlowski

doi:10.1021/jo502408z

Recent Advances in Asymmetric Catalytic Methods for the Formation of Acyclic α,α-Disubstituted α-Amino Acids

J Org Chem. 2015 Jan 2;80(1):1-7. doi: 10.1021/jo502408z. Epub 2014 Dec 11.

Authors

Alison E Metz¹, Marisa C Kozlowski¹

Affiliation

¹ Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

PMID: 25496236
DOI: 10.1021/jo502408z

Abstract

Because of their greater stability and unique conformational properties, unnatural amino acids are highly valued by pharmaceutical, biological, and organic chemists. This synopsis surveys the various catalytic methods used to access enantioenriched, acyclic α,α-disubstituted α-amino acids with a focus on the processes developed since 2007, when the last major reviews in this area were published.

MeSH terms

Amino Acids / chemical synthesis*
Amino Acids / chemistry
Catalysis
Molecular Structure

Substances

Amino Acids