An ER clamp for endosome fission

EMBO J. 2015 Jan 13;34(2):136-7. doi: 10.15252/embj.201490707. Epub 2014 Dec 12.

Abstract

Endosomes are known to undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. A recent paper (Rowland et al, 2014) shows that contact sites between endosomes and the endoplasmic reticulum (ER) define the position and timing for fission. This uncovers an unanticipated role for the ER in controlling endosomal sorting and maturation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Endoplasmic Reticulum / metabolism*
  • Endosomes / metabolism*
  • Humans