Building through breaking: the development of cancer neochromosomes

Joshua J Waterfall; Paul S Meltzer

doi:10.1016/j.ccell.2014.10.013

Building through breaking: the development of cancer neochromosomes

Cancer Cell. 2014 Nov 10;26(5):593-5. doi: 10.1016/j.ccell.2014.10.013. Epub 2014 Nov 10.

Authors

Joshua J Waterfall¹, Paul S Meltzer²

Affiliations

¹ Genetics Branch, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892, USA.
² Genetics Branch, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892, USA. Electronic address: pmeltzer@mail.nih.gov.

PMID: 25517741
DOI: 10.1016/j.ccell.2014.10.013

Abstract

In this issue of Cancer Cell, Garsed and colleagues combine chromosome flow sorting and deep sequencing to characterize the structure of oncogene-containing neochromosomes in liposarcoma and provide evidence that they are generated by a combination of multiple dynamic and destructive processes.

Publication types

Comment

MeSH terms

Chromosomes, Human / genetics*
Female
Humans
Liposarcoma / genetics*
Retroperitoneal Neoplasms / genetics*