Cardiac energetic impairment in heart disease and the potential role of metabolic modulators: a review for clinicians

Circ Cardiovasc Genet. 2014 Oct;7(5):720-8. doi: 10.1161/CIRCGENETICS.114.000221.

Abstract

Cardiac energetic impairment is a frequent finding in patients with both inherited and acquired diseases of heart muscle. In this review the mechanisms of energy generation in the healthy heart and their disturbances in heart muscle diseases are described. Therapeutic agents targeted at correcting cardiac energetic impairment are discussed.

Keywords: drug therapy; energy metabolism; perhexiline; reperfusion injury.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / chemistry
  • Animals
  • Cardiology / methods*
  • Carnitine O-Palmitoyltransferase / antagonists & inhibitors
  • Electron Transport
  • Fatty Acids / chemistry
  • Heart / physiology*
  • Heart Diseases / physiopathology*
  • Humans
  • Hypoxia
  • Insulin Resistance
  • Oxygen / chemistry
  • Reactive Oxygen Species

Substances

  • Fatty Acids
  • Reactive Oxygen Species
  • Adenosine Triphosphate
  • Carnitine O-Palmitoyltransferase
  • Oxygen