Epstein-Barr virus-associated smooth muscle tumors in children following solid organ transplantation: a review

Pediatr Transplant. 2015 Mar;19(2):235-43. doi: 10.1111/petr.12426. Epub 2015 Jan 9.

Abstract

EBV-SMT are a rare entity following organ transplantation. Given the rarity of the tumor, there is no standard approach to diagnosis and treatment. A literature search identified 28 reported cases of EBV-SMT in addition to our own experience with one case. The aim of this review is to summarize the existing data regarding pathogenesis, diagnosis, and treatment.

Keywords: Epstein-Barr virus; immunosuppression; muscle tumor; organ transplantation; smooth; tumor virus infection.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Child
  • Child, Preschool
  • Epstein-Barr Virus Infections / etiology*
  • Herpesvirus 4, Human*
  • Humans
  • Immunosuppression Therapy
  • Immunosuppressive Agents / therapeutic use
  • Infant
  • Kidney Transplantation / adverse effects
  • Lymphoproliferative Disorders / etiology
  • Magnetic Resonance Imaging
  • Male
  • Muscle Neoplasms / etiology*
  • Muscle Neoplasms / virology
  • Organ Transplantation / adverse effects*
  • Postoperative Complications
  • Prognosis
  • Treatment Outcome

Substances

  • Immunosuppressive Agents