Abnormalities of selenium but not of copper homeostasis may drive tissue fibrosis in patients with systemic sclerosis

Michael Hughes; Garth J S Cooper; Jack Wilkinson; Paul New; John M Guy; Ariane L Herrick

doi:10.1093/rheumatology/keu470

Abnormalities of selenium but not of copper homeostasis may drive tissue fibrosis in patients with systemic sclerosis

Rheumatology (Oxford). 2015 Apr;54(4):747-8. doi: 10.1093/rheumatology/keu470. Epub 2015 Jan 18.

Authors

Michael Hughes¹, Garth J S Cooper², Jack Wilkinson³, Paul New³, John M Guy³, Ariane L Herrick³

Affiliations

¹ Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, Research and Development, Rheumatology Directorate and Department of Clinical Biochemistry, Salford Royal NHS Foundation Trust, Salford, UK. michael.hughes-6@postgrad.manchester.ac.uk.
² Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, Research and Development, Rheumatology Directorate and Department of Clinical Biochemistry, Salford Royal NHS Foundation Trust, Salford, UK. Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, Research and Development, Rheumatology Directorate and Department of Clinical Biochemistry, Salford Royal NHS Foundation Trust, Salford, UK.
³ Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, Research and Development, Rheumatology Directorate and Department of Clinical Biochemistry, Salford Royal NHS Foundation Trust, Salford, UK.

PMID: 25602061
DOI: 10.1093/rheumatology/keu470

No abstract available

Publication types

Letter

MeSH terms

Adult
Aged
Case-Control Studies
Copper / metabolism*
Female
Fibrosis / metabolism*
Homeostasis
Humans
Male
Middle Aged
Scleroderma, Systemic / metabolism*
Selenium / metabolism*
Serum Albumin

Substances

Serum Albumin
Copper
Selenium