Cytokine profiles in Mycoplasma pneumoniae infection-associated hemophagocytic lymphohistiocytosis

J Microbiol Immunol Infect. 2016 Oct;49(5):813-816. doi: 10.1016/j.jmii.2014.11.015. Epub 2014 Dec 11.

Abstract

A 3-year-old boy with Mycoplasma pneumoniae infection associated with hemophagocytic lymphohistiocytosis (MP-HLH) presented with an elevated level of serum interleukin-12 (IL-12) and lower levels of interferon-γ and IL-10 compared to patients with Epstein-Barr virus infection associated with HLH (EBV-HLH). Unlike the patients with EBV-HLH, CD8+ CD5low HLA-DR++ T cells were not detected in our pediatric patient. Thus, the pathophysiology of MP-HLH may differ from that of EBV-HLH.

Keywords: CD8; Mycoplasma pneumoniae; cytokine; hemophagocytic lymphohistiocytosis.

Publication types

  • Case Reports

MeSH terms

  • CD8-Positive T-Lymphocytes / immunology
  • Child, Preschool
  • Humans
  • Interferon-gamma / blood*
  • Interleukin-10 / blood*
  • Interleukin-12 Subunit p35 / blood*
  • Killer Cells, Natural / immunology
  • Lymphohistiocytosis, Hemophagocytic / blood
  • Lymphohistiocytosis, Hemophagocytic / complications
  • Lymphohistiocytosis, Hemophagocytic / diagnosis*
  • Male
  • Mycoplasma Infections / blood
  • Mycoplasma Infections / diagnosis*
  • Mycoplasma Infections / microbiology
  • Mycoplasma pneumoniae / immunology*

Substances

  • IL10 protein, human
  • IL12A protein, human
  • Interleukin-12 Subunit p35
  • Interleukin-10
  • Interferon-gamma