Tyrosine hydroxylase and levodopa responsive dystonia

J Neurol Neurosurg Psychiatry. 1989 Jan;52(1):112-4. doi: 10.1136/jnnp.52.1.112.

Abstract

It has been suggested that a form of inherited dystonia responsive to levodopa might be due to an abnormality of tyrosine hydroxylase gene. This hypothesis has been tested using a cDNA tyrosine hydroxylase gene probe in three families with this disorder. No evidence for genetic linkage between the disease and tyrosine hydroxylase loci was found; it is possible that the disorder results from a post-transcriptional defect confined to the brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, Pair 11
  • DNA Probes
  • Dystonia / drug therapy
  • Dystonia / genetics*
  • Genetic Linkage
  • Humans
  • Levodopa / therapeutic use*
  • Parkinson Disease / drug therapy
  • Parkinson Disease / genetics*
  • Pedigree
  • Polymorphism, Restriction Fragment Length
  • Tyrosine 3-Monooxygenase / genetics*

Substances

  • DNA Probes
  • Levodopa
  • Tyrosine 3-Monooxygenase