Abstract
Neonatal fungal and viral infections are associated with mortality and neurologic impairment among survivors. Advances in pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobial medications have led to improved dosing guidance for neonates. This article discusses the basic PK/PD properties and dosing of the most common antifungal and antiviral medications used in neonates.
Keywords:
Acyclovir; Amphotericin; Echinocandin; Fluconazole; Ganciclovir; Neonate.
Copyright © 2015 Elsevier Inc. All rights reserved.
MeSH terms
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Acyclovir / administration & dosage
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Acyclovir / pharmacokinetics
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Amphotericin B / administration & dosage
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Amphotericin B / pharmacokinetics
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Antifungal Agents / administration & dosage*
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Antifungal Agents / pharmacokinetics
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Antiviral Agents / administration & dosage*
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Antiviral Agents / pharmacokinetics
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Candidiasis, Invasive / drug therapy*
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Cytomegalovirus Infections / drug therapy*
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Deoxycholic Acid / administration & dosage
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Deoxycholic Acid / pharmacokinetics
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Drug Combinations
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Fluconazole / administration & dosage
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Fluconazole / pharmacokinetics
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Ganciclovir / administration & dosage
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Ganciclovir / analogs & derivatives
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Ganciclovir / pharmacokinetics
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Herpes Simplex / drug therapy*
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Humans
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Infant
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Infant, Newborn
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Mycoses / drug therapy
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Practice Guidelines as Topic*
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Pregnancy Complications, Infectious / drug therapy*
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Valganciclovir
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Virus Diseases / drug therapy
Substances
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Antifungal Agents
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Antiviral Agents
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Drug Combinations
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Deoxycholic Acid
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Amphotericin B
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amphotericin B, deoxycholate drug combination
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Fluconazole
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Valganciclovir
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Ganciclovir
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Acyclovir