Suppression of antibiotic resistance acquisition by combined use of antibiotics

Shingo Suzuki; Takaaki Horinouchi; Chikara Furusawa

doi:10.1016/j.jbiosc.2015.02.003

Suppression of antibiotic resistance acquisition by combined use of antibiotics

J Biosci Bioeng. 2015 Oct;120(4):467-9. doi: 10.1016/j.jbiosc.2015.02.003. Epub 2015 Mar 5.

Authors

Shingo Suzuki¹, Takaaki Horinouchi¹, Chikara Furusawa²

Affiliations

¹ Laboratory for Multiscale Biosystem Dynamics, Quantitative Biology Center (QBiC), RIKEN, 6-2-3 Furuedai, Suita, Osaka 565-0874, Japan.
² Laboratory for Multiscale Biosystem Dynamics, Quantitative Biology Center (QBiC), RIKEN, 6-2-3 Furuedai, Suita, Osaka 565-0874, Japan. Electronic address: Chikara.furusawa@riken.jp.

PMID: 25746894
DOI: 10.1016/j.jbiosc.2015.02.003

Abstract

We analyzed the effect of combinatorial use of antibiotics with a trade-off relationship of resistance, i.e., resistance acquisition to one drug causes susceptibility to the other drug, and vice versa, on the evolution of antibiotic resistance. We demonstrated that this combinatorial use of antibiotics significantly suppressed the acquisition of resistance.

Keywords: Antibiotics; Escherichia coli; Experimental evolution; Resistance; Trade-off.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / administration & dosage*
Anti-Bacterial Agents / pharmacology*
Biological Evolution
Directed Molecular Evolution
Drug Resistance, Microbial / drug effects*
Drug Therapy, Combination
Escherichia coli / drug effects*
Escherichia coli / metabolism*
Microbial Sensitivity Tests

Substances

Anti-Bacterial Agents