Abstract
A tetrahydrofuro[3,2-d]oxazole scaffold was synthesized efficiently and stereoselectively. The tandem ionic hydrogenation, ketalization, and intramolecular cyclization of arene-1,4-diones with a combination of TiCl4/Et3SiH give facile access to tetrahydrofuro[3,2-d]oxazole derivatives in good yields at room temperature.
MeSH terms
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Catalysis
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Crystallography, X-Ray
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Cyclization
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Furans / chemical synthesis*
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Furans / chemistry
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Hydrogenation
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Models, Molecular
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Oxazoles / chemical synthesis*
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Oxazoles / chemistry
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Stereoisomerism
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Titanium / chemistry*
Substances
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Furans
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Oxazoles
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tetrahydro-2-furancarboxylic acid
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titanium tetrachloride
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Titanium