Stereoselective synthesis of (all-Z)-hentriaconta-3,6,9,12,15,19,22,25,28-nonaene

Org Biomol Chem. 2015 Apr 28;13(16):4680-5. doi: 10.1039/c5ob00313j.

Abstract

Several microorganisms produce small quantities of polyunsaturated hydrocarbons and such natural products are of interest. Starting from the ethyl ester of eicosapentaenoic acid, the total synthesis of the natural product (all-Z)-hentriaconta-3,6,9,12,15,19,22,25,28-nonaene has been achieved in eight steps and 15% overall yield. The synthesis is based on a stereoselective Wittig reaction and confirms the all-Z-configuration of the nine double bonds in this highly unsaturated natural product.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Biological Products / chemical synthesis*
  • Biological Products / chemistry
  • Drug Design
  • Eicosapentaenoic Acid / analogs & derivatives*
  • Eicosapentaenoic Acid / chemistry
  • Esters / chemistry
  • Fatty Acids, Unsaturated / chemistry
  • Hydrocarbons / chemistry*
  • Lipid Metabolism
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Stereoisomerism

Substances

  • Aldehydes
  • Biological Products
  • Esters
  • Fatty Acids, Unsaturated
  • Hydrocarbons
  • hentriaconta-3,6,9,12,15,19,22,25,28-nonene
  • Eicosapentaenoic Acid