ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout

Hirotaka Matsuo; Hiroyuki Tomiyama; Wataru Satake; Toshinori Chiba; Hiroyuki Onoue; Yusuke Kawamura; Akiyoshi Nakayama; Seiko Shimizu; Masayuki Sakiyama; Manabu Funayama; Kenya Nishioka; Toru Shimizu; Kenichi Kaida; Keiko Kamakura; Tatsushi Toda; Nobutaka Hattori; Nariyoshi Shinomiya

doi:10.1002/acn3.167

ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout

Ann Clin Transl Neurol. 2015 Mar;2(3):302-6. doi: 10.1002/acn3.167. Epub 2015 Jan 19.

Authors

Hirotaka Matsuo¹, Hiroyuki Tomiyama², Wataru Satake³, Toshinori Chiba¹, Hiroyuki Onoue⁴, Yusuke Kawamura¹, Akiyoshi Nakayama¹, Seiko Shimizu¹, Masayuki Sakiyama¹, Manabu Funayama², Kenya Nishioka², Toru Shimizu⁵, Kenichi Kaida⁴, Keiko Kamakura⁶, Tatsushi Toda³, Nobutaka Hattori², Nariyoshi Shinomiya¹

Affiliations

¹ Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College Tokorozawa, Japan.
² Department of Neurology, Juntendo University School of Medicine Tokyo, Japan.
³ Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine Kobe, Japan.
⁴ Department of Internal Medicine, National Defense Medical College Tokorozawa, Japan.
⁵ Midorigaoka Hospital Osaka, Japan.
⁶ Department of Internal Medicine, National Defense Medical College Tokorozawa, Japan ; Department of Physical Therapy, School of Health Sciences, Tokyo University of Technology Tokyo, Japan.

Abstract

Uric acid (urate) has been suggested to play a protective role in Parkinson's disease onset through its antioxidant activity. Dysfunction of ABCG2, a high-capacity urate exporter, is a major cause for early-onset gout based on hyperuricemia. In this study, the effects of a dysfunctional ABCG2 variant (Q141K, rs2231142) were analyzed on the ages at onset of gout patients (N = 507) and Parkinson's disease patients (N = 1015). The Q141K variant hastened the gout onset (P = 0.0027), but significantly associated with later Parkinson's disease onset (P = 0.025). Our findings will be helpful for development of more effective prevention of Parkinson's disease.