Anti-toll like receptor 4 (TLR4) therapy diminishes cardiac remodeling regardless of changes in blood pressure in spontaneously hypertensive rats (SHR)

Cinthya Echem; Gisele Facholi Bomfim; Graziela Scalianti Ceravolo; Maria Aparecida Oliveira; Rosângela Aparecida Santos-Eichler; Luiz Roberto Bechara; Mariana Matera Veras; Paulo Hilário Nascimento Saldiva; Julio Cesar Ferreira; Eliana Hiromi Akamine; Zuleica Bruno Fortes; Ana Paula Dantas; Maria Helena Catelli de Carvalho

doi:10.1016/j.ijcard.2015.03.190

Anti-toll like receptor 4 (TLR4) therapy diminishes cardiac remodeling regardless of changes in blood pressure in spontaneously hypertensive rats (SHR)

Int J Cardiol. 2015:187:243-5. doi: 10.1016/j.ijcard.2015.03.190. Epub 2015 Mar 18.

Authors

Affiliations

¹ Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
² Institute of Health Sciences, Federal University of Mato Grosso, Sinop, Brazil.
³ Department of Physiology Sciences, State University of Londrina, Londrina, Brazil.
⁴ School of Medicine, University of São Paulo, São Paulo, Brazil.
⁵ Group of Atherosclerosis and Coronary disease, Institut Clinic del Torax, Institut 12 d'Investigaciones Biomédiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
⁶ Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: mhcarval@icb.usp.br.

PMID: 25838224
DOI: 10.1016/j.ijcard.2015.03.190

No abstract available

Keywords: Arterial hypertension; Cardiac fibrosis; Cardiac hypertrophy; Cardiac inflammation; Spontaneously hypertensive rats (SHR); Toll-like receptor 4 (TLR4).

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Atrial Remodeling / drug effects*
Blood Pressure
Hypertension / physiopathology
Male
Rats
Rats, Inbred SHR
Toll-Like Receptor 4 / antagonists & inhibitors*

Substances

Tlr4 protein, rat
Toll-Like Receptor 4