Is there a role for monocyte chemoattractant protein-1 in delirium? Novel observations in elderly hip fracture patients

Kjersti Skrede; Torgeir Bruun Wyller; Leiv Otto Watne; Ingebjørg Seljeflot; Vibeke Juliebø

doi:10.1186/s13104-015-1129-5

Is there a role for monocyte chemoattractant protein-1 in delirium? Novel observations in elderly hip fracture patients

BMC Res Notes. 2015 May 6:8:186. doi: 10.1186/s13104-015-1129-5.

Authors

Kjersti Skrede^{1

2

3}, Torgeir Bruun Wyller^{4

5

6}, Leiv Otto Watne^{7

8

9}, Ingebjørg Seljeflot^{10

11}, Vibeke Juliebø^{12

13

14}

Affiliations

¹ Oslo Delirium Research Group, Oslo, Norway. kjersti.skrede@so-hf.no.
² Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway. kjersti.skrede@so-hf.no.
³ Faculty of Medicine, University of Oslo, Oslo, Norway. kjersti.skrede@so-hf.no.
⁴ Oslo Delirium Research Group, Oslo, Norway. t.b.wyller@medisin.uio.no.
⁵ Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway. t.b.wyller@medisin.uio.no.
⁶ Faculty of Medicine, University of Oslo, Oslo, Norway. t.b.wyller@medisin.uio.no.
⁷ Oslo Delirium Research Group, Oslo, Norway. l.o.watne@gmail.com.
⁸ Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway. l.o.watne@gmail.com.
⁹ Faculty of Medicine, University of Oslo, Oslo, Norway. l.o.watne@gmail.com.
¹⁰ Center for Clinical Heart Research, Oslo University Hospital, Oslo, Norway. ingebjorg.seljeflot@ous-hf.no.
¹¹ Department of Cardiology, Oslo University Hospital, Oslo, Norway. ingebjorg.seljeflot@ous-hf.no.
¹² Oslo Delirium Research Group, Oslo, Norway. v.juliebo@gmail.com.
¹³ Faculty of Medicine, University of Oslo, Oslo, Norway. v.juliebo@gmail.com.
¹⁴ Department of Cardiology, Oslo University Hospital, Oslo, Norway. v.juliebo@gmail.com.

Abstract

Background: Delirium is common, associated with poor outcome, but its pathophysiology remains obscure. The aim of the present study was to study a possible role of monocyte chemoattractant protein-1 (MCP-1) in the development of delirium.

Findings: A prospective cohort of 19 hip fracture patients (median age 83 years) were screened for delirium daily by validated methods. MCP-1 was measured on arrival and postoperatively. The number of patients with a raise in MCP-1 was statistically significantly higher in the group with delirium in the postoperative phase compared to the no-delirium group (5/6 vs. 1/7, p = .03).

Conclusions: MCP-1 might play a role in the development of delirium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Chemokine CCL2 / blood*
Delirium / blood*
Female
Hip Fractures / blood*
Hip Fractures / surgery
Humans
Male
Postoperative Complications / etiology
Postoperative Period
Preoperative Care

Substances

CCL2 protein, human
Chemokine CCL2