Exercise training modifies gut microbiota in normal and diabetic mice

Appl Physiol Nutr Metab. 2015 Jul;40(7):749-52. doi: 10.1139/apnm-2014-0452. Epub 2015 Feb 18.

Abstract

Cecal microbiota from type 2 diabetic (db/db) and control (db/(+)) mice was obtained following 6 weeks of sedentary or exercise activity. qPCR analysis revealed a main effect of exercise, with greater abundance of select Firmicutes species and lower Bacteroides/Prevotella spp. in both normal and diabetic exercised mice compared with sedentary counterparts. Conversely, Bifidobacterium spp. was greater in exercised normal but not diabetic mice (exercise × diabetes interaction). How exercise influences gut microbiota requires further investigation.

Keywords: diabetes; diabète; exercice physique; exercise; flore; microbiota.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Diabetes Mellitus, Experimental / microbiology*
  • Disease Models, Animal
  • Gastrointestinal Microbiome*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Physical Conditioning, Animal / statistics & numerical data*