The Gender-Dependent Association between Obesity and Age-Related Cataracts in Middle-Aged Korean Adults

PLoS One. 2015 May 14;10(5):e0124262. doi: 10.1371/journal.pone.0124262. eCollection 2015.

Abstract

The aim of this study was to investigate the association of central and abdominal obesity with the prevalence of cataracts in a middle-aged Korean population. This retrospective cross-sectional study was based on the data collected from the Korea National Health and Nutrition Examination Survey 2008-2009, in which 4,914 subjects were examined. Ophthalmological examinations were performed to determine the presence of a nuclear, cortical, or posterior subcapsular cataract. Both general obesity (a body mass index ≥25 kg/m2) and abdominal obesity (a waist circumference ≥90 cm for men and ≥80 cm for women) were significantly associated with the occurrence of cataracts among middle-aged women [adjusted odds ratio (aOR), 1.32; 95% confidence interval (CI), 1.03-1.69; and aOR, 1.40; 95% CI, 1.06-1.85, respectively], while abdominal obesity was significantly inversely associated with the occurrence of cataracts among middle-aged men (aOR, 0.76; 95% CI, 0.58-1.01; and aOR, 0.66; 95% CI, 0.49-0.89, respectively). We report a difference in the association between obesity and the prevalence of cataracts based on gender.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aging / pathology*
  • Body Mass Index
  • Cataract / complications
  • Cataract / epidemiology*
  • Cataract / pathology
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nutrition Surveys
  • Obesity / complications
  • Obesity / epidemiology*
  • Obesity / pathology
  • Odds Ratio
  • Prevalence
  • Republic of Korea / epidemiology
  • Retrospective Studies
  • Risk Factors
  • Sex Factors

Grants and funding

This work was financially supported by research grants from the Catholic Medical Center Research Foundation made in the program year of 2011, and Korea Health Industry Development Institute (KHIDI), Grant number H13C0307.