KO(t)Bu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones

Abhimanyu Yadav; Ajay Verma; Saket Patel; Amit Kumar; Vandana Rathore; Meenakshi; Shailesh Kumar; Sangit Kumar

doi:10.1039/c5cc02964c

KO(t)Bu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones

Chem Commun (Camb). 2015 Jul 25;51(58):11658-61. doi: 10.1039/c5cc02964c. Epub 2015 Jun 23.

Authors

Abhimanyu Yadav¹, Ajay Verma, Saket Patel, Amit Kumar, Vandana Rathore, Meenakshi, Shailesh Kumar, Sangit Kumar

Affiliation

¹ Department of Chemistry, Indian Institute of Science Education and Research (IISER) Bhopal, Indore By-pass Road, Bhauri, Bhopal, Madhya Pradesh 462 066, India. sangitkumar@iiserb.ac.in.

PMID: 26100391
DOI: 10.1039/c5cc02964c

Abstract

The KO(t)Bu-mediated annulation of acetonitrile with aldehyde was observed, in which the cleavage of four C(sp(3))-H bonds occurred and a total of eight new bonds were formed during the synthesis of substituted dihydropyridinones in the presence of peroxide. Furthermore, dihydropyridinones have been transformed into pyridinones using KO(t)Bu in DMSO.