Spectroscopic study on interaction between three cationic surfactants with different alkyl chain lengths and DNA

Spectrochim Acta A Mol Biomol Spectrosc. 2015:151:237-46. doi: 10.1016/j.saa.2015.06.114. Epub 2015 Jun 29.

Abstract

In this study, the interaction between cationic surfactants with different alkyl chain lengths, such as hexyltrimethyl ammonium bromide (HTAB), dodecyltrimethyl ammonium bromide (DTAB) and cetyltrimethyl ammonium bromide (CTAB), and DNA was investigated by UV-vis spectroscopy, fluorescence spectroscopy and viscosity techniques. The results showed that these three cationic surfactants with different hydrocarbon chain lengths could all interact with DNA. Their binding modes were estimated and their interaction strength was compared. In addition, the effects of the surfactant, NaCl and phosphate ion concentrations on the interaction were reviewed. It is wished that this work would provide some valuable references to investigate the influence of cationic surfactants with different alkyl chain lengths on DNA.

Keywords: Cationic surfactant; Deoxyribonucleic acid (DNA); Interaction; Spectroscopy; Viscosity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cations / chemistry*
  • Cetrimonium
  • Cetrimonium Compounds / chemistry
  • Cetrimonium Compounds / metabolism
  • DNA / chemistry*
  • DNA / metabolism
  • Phosphates / chemistry*
  • Phosphates / metabolism
  • Quaternary Ammonium Compounds / chemistry
  • Quaternary Ammonium Compounds / metabolism
  • Sodium Chloride / chemistry*
  • Sodium Chloride / metabolism
  • Spectrometry, Fluorescence
  • Spectrophotometry, Ultraviolet
  • Surface-Active Agents / chemistry*
  • Surface-Active Agents / metabolism

Substances

  • Cations
  • Cetrimonium Compounds
  • Phosphates
  • Quaternary Ammonium Compounds
  • Surface-Active Agents
  • decyltrimethylammonium
  • Sodium Chloride
  • DNA
  • Cetrimonium