Delineating cancer evolution with single-cell sequencing

Nicholas E Navin

doi:10.1126/scitranslmed.aac8319

Delineating cancer evolution with single-cell sequencing

Sci Transl Med. 2015 Jul 15;7(296):296fs29. doi: 10.1126/scitranslmed.aac8319.

Author

Nicholas E Navin¹

Affiliation

¹ Department of Genetics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA. Department of Bioinformatics and Computational Biology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA. Graduate Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. nnavin@mdanderson.org.

Abstract

Single-cell sequencing methods are revolutionizing cancer research and medicine by providing powerful tools to investigate intratumor heterogeneity and rare subpopulations.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms / genetics*
Breast Neoplasms / pathology*
DNA Copy Number Variations
Disease Progression
Female
Gene Dosage
Genetic Heterogeneity
Genomics
High-Throughput Nucleotide Sequencing / methods*
Humans
Mutation
Phenotype
Sequence Analysis, DNA
Single-Cell Analysis*
Translational Research, Biomedical

Abstract

Publication types

MeSH terms

Grants and funding