Reconsidering DNA Polymerases at the Replication Fork in Eukaryotes

Mol Cell. 2015 Jul 16;59(2):139-41. doi: 10.1016/j.molcel.2015.07.004.

Abstract

The distribution of DNA polymerase activities at the eukaryotic DNA replication fork was "established," but recent genetic studies in this issue of Molecular Cell raise questions about which polymerases are copying the leading and lagging strand templates (Johnson et al, 2015).

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • DNA Polymerase III / metabolism*
  • DNA Replication*
  • DNA, Fungal / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism*

Substances

  • DNA, Fungal
  • POL3 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • DNA Polymerase III