An exploratory association study of the influence of noradrenergic genes and childhood trauma in Borderline Personality Disorder

Psychiatry Res. 2015 Sep 30;229(1-2):589-92. doi: 10.1016/j.psychres.2015.07.046. Epub 2015 Jul 21.

Abstract

This study investigated the possible association of 40 polymorphisms within 4 noradrenergic genes with BPD risk and the modulating effect of childhood trauma on these associations in 481 BPD subjects and 442 controls. COMT rs5993882, DBH rs77905 and SLC6A2 rs1814270 showed associations with BPD, which were modulated by childhood trauma. However, none of these findings survived Bonferroni correction. Further investigation is needed to clarify the involvement of these genes in BPD pathogenesis.

Keywords: Borderline Personality Disorder; Childhood trauma; Noradrenergic system.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Borderline Personality Disorder / epidemiology*
  • Borderline Personality Disorder / genetics*
  • Borderline Personality Disorder / psychology
  • Catechol O-Methyltransferase / genetics*
  • Child
  • Child Abuse* / psychology
  • Dopamine beta-Hydroxylase / genetics
  • Female
  • Genetic Association Studies / methods*
  • Humans
  • Male
  • Middle Aged
  • Norepinephrine Plasma Membrane Transport Proteins / genetics*
  • Polymorphism, Genetic
  • Promoter Regions, Genetic / genetics
  • Retrospective Studies

Substances

  • Norepinephrine Plasma Membrane Transport Proteins
  • SLC6A2 protein, human
  • Dopamine beta-Hydroxylase
  • COMT protein, human
  • Catechol O-Methyltransferase