Dietziamides, novel tetramic acid dimers from Dietzia timorensis MZ-3 with antioxidative activity

Shotaro Hoshino; Toshiyuki Wakimoto; Huiping Zhang; Fumiaki Hayashi; Masahiro Okada; Ikuro Abe

doi:10.1016/j.bmcl.2015.07.035

Dietziamides, novel tetramic acid dimers from Dietzia timorensis MZ-3 with antioxidative activity

Bioorg Med Chem Lett. 2015 Sep 15;25(18):3953-5. doi: 10.1016/j.bmcl.2015.07.035. Epub 2015 Jul 18.

Authors

Shotaro Hoshino¹, Toshiyuki Wakimoto², Huiping Zhang³, Fumiaki Hayashi³, Masahiro Okada¹, Ikuro Abe⁴

Affiliations

¹ Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
² Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo Nishi 6-chome, Kita-ku, Sapporo 060-0812, Japan.
³ RIKEN Center for Life Science Technologies, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.
⁴ Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: abei@mol.f.u-tokyo.ac.jp.

PMID: 26220156
DOI: 10.1016/j.bmcl.2015.07.035

Abstract

Dietziamides A and B, two novel tetramic acid dimers, were isolated from the rare actinomycetes Dietzia timorensis MZ-3 in the course of our HPLC-diode array screening of our collection of terrestrial actinomycetes. The spectroscopic analysis revealed the chemical structures of the first secondary metabolites characterized in the genus Dietzia. Dietziamides A and B showed moderate DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activities.

Keywords: Dietzia timorensis; Dietziamides; Rare actinomycetes; Secondary metabolites; Tetramic acid.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actinomycetales / chemistry*
Antioxidants / chemistry*
Antioxidants / isolation & purification
Antioxidants / metabolism
Dimerization
Lactams / chemistry*
Lactams / isolation & purification
Lactams / metabolism
Molecular Structure

Substances

Antioxidants
Lactams
dietziamide A
dietziamide B