Changes in Metabolic Hormones in Malaysian Young Adults following Helicobacter pylori Eradication

PLoS One. 2015 Aug 20;10(8):e0135771. doi: 10.1371/journal.pone.0135771. eCollection 2015.

Abstract

Background: More than half of the world's adults carry Helicobacter pylori. The eradication of H. pylori may affect the regulation of human metabolic hormones. The aim of this study was to evaluate the effect of H. pylori eradication on meal-associated changes in appetite-controlled insulinotropic and digestive hormones, and to assess post-eradication changes in body mass index as part of a currently on-going multicentre ESSAY (Eradication Study in Stable Adults/Youths) study.

Methods: We enrolled 29 H. pylori-positive young adult (18-30 year-old) volunteer subjects to evaluate the effect of H. pylori eradication on meal-associated changes on eight gastrointestinal hormones, using a multiplex bead assay. Changes in body mass index and anthropometric measurements were recorded, pre- and post-eradication therapy.

Results: Pre-prandial active amylin, total peptide YY (PYY) and pancreatic polypeptide (PP) levels were significantly elevated 12 months post-eradication compared with baseline (n = 18; Wilcoxon's signed rank test, p<0.05). Four of the post-prandial gut metabolic hormones levels (GLP-1, total PYY, active amylin, PP) were significantly higher 12 months post-eradication compared to baseline (n = 18; p<0.05). Following H. pylori eradication, the BMI and anthropometric values did not significantly change.

Conclusions: Our study indicates that H. pylori eradication was associated with long-term disturbance in three hormones (active amylin, PP and total PYY) both pre- and post-prandially and one hormone (GLP-1) post-prandially. Longer post-eradication monitoring is needed to investigate the long-term impact of the observed hormonal changes on metabolic homeostasis.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Appetite / physiology
  • Body Mass Index
  • Eating / physiology
  • Female
  • Gastrointestinal Hormones / metabolism*
  • Helicobacter Infections / complications*
  • Helicobacter Infections / metabolism*
  • Helicobacter Infections / microbiology
  • Helicobacter pylori / pathogenicity
  • Humans
  • Islet Amyloid Polypeptide / metabolism
  • Malaysia
  • Male
  • Pancreatic Polypeptide / metabolism
  • Peptide YY / metabolism
  • Young Adult

Substances

  • Gastrointestinal Hormones
  • Islet Amyloid Polypeptide
  • Peptide YY
  • Pancreatic Polypeptide

Grants and funding

This study was supported by the University of Malaya-Ministry of Education (UM-MOE) High Impact Research (HIR) Grant UM.C/HIR/MOE/13/4 (HIR Account No: H-50001-00-A000029), by the Diane Belfer Program for Human Microbial Ecology, the C and D fund (philanthropic (non-commercial) anonymous donors), and the Knapp Family Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would like to also declare that one of the authors is employed by a commercial company called BP Healthcare. This commercial affiliation provided support in the form of salaries for author BHP, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of authors are articulated in the "Author contributions" section.