The Effect of Menopausal Hormone Therapies on Breast Cancer: Avoiding the Risk

Valerie A Flores; Hugh S Taylor

doi:10.1016/j.ecl.2015.05.007

The Effect of Menopausal Hormone Therapies on Breast Cancer: Avoiding the Risk

Endocrinol Metab Clin North Am. 2015 Sep;44(3):587-602. doi: 10.1016/j.ecl.2015.05.007. Epub 2015 Jun 23.

Authors

Valerie A Flores¹, Hugh S Taylor²

Affiliations

¹ Women and Infants Hospital, Warren Alpert Medical School of Brown University, 222 Richmond Street, Providence, RI 02903, USA.
² Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address: hugh.taylor@yale.edu.

Abstract

Estrogen and P treatment results in greater risk of breast cancer than placebo. Treatment with estrogen alone does not increase the risk of breast cancer, may be used by women who have had a hysterectomy, and may even result in a decreased risk of breast cancer. Continued research seeks to improve the understanding of the interplay between estrogen and progestogens that predispose to adverse effects on breast tissue. Caution over this hypothesized benefit is warranted until it is substantiated by data on the incidence of breast cancer in tissue selective estrogen complex users.

Keywords: Breast cancer; Estrogens; Hormone therapy; Menopause; Progestogen.

Publication types

Review

MeSH terms

Breast Neoplasms / chemically induced*
Estrogen Replacement Therapy / adverse effects*
Female
Humans
Menopause*
Risk Factors

Abstract

Publication types

MeSH terms

Grants and funding