Similar Subgroups Based on Cognitive Performance Parse Heterogeneity in Adults With ADHD and Healthy Controls

J Atten Disord. 2018 Feb;22(3):281-292. doi: 10.1177/1087054715602332. Epub 2015 Sep 14.

Abstract

Objective: To characterize heterogeneity in adults with ADHD we aimed to identify subgroups within the adult ADHD spectrum, which differ in their cognitive profile.

Method: Neuropsychological data from adults with ADHD ( n = 133) and healthy control participants ( n = 132) were used in a confirmatory factor analysis. The resulting six cognitive factors were correlated across participants to form networks. We used a community detection algorithm to cluster these networks into subgroups.

Results: Both the ADHD and control group separated into three profiles that differed in cognitive performance. Profile 1 was characterized by aberrant attention and inhibition, profile 2 by increased delay discounting, and profile 3 by atypical working memory and verbal fluency.

Conclusion: Our findings suggest that qualitative differences in neuropsychological performance exist in both control and ADHD adult individuals. This extends prior findings in children with and without ADHD and provides a framework to parse participants into well-defined subgroups.

Keywords: adult ADHD; delay discounting; executive functions; heterogeneity; neuropsychology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Attention / physiology*
  • Attention Deficit Disorder with Hyperactivity / psychology*
  • Case-Control Studies
  • Child
  • Cognition / physiology*
  • Delay Discounting*
  • Executive Function
  • Female
  • Humans
  • Inhibition, Psychological*
  • Male
  • Memory, Short-Term / physiology*
  • Neuropsychological Tests*