[18F]-NaF PET/CT imaging in cardiac amyloidosis

J Nucl Cardiol. 2016 Aug;23(4):846-9. doi: 10.1007/s12350-015-0287-0. Epub 2015 Sep 24.

Abstract

Cardiac amyloidosis (CA) is recognized as a common cause of restrictive cardiomyopathy and heart failure due to the deposition of insoluble proteins in the myocardial interstitium. We emphasize the role of [18F]-sodium fluoride (NaF) PET/CT as a potential noninvasive tool to identify and differentiate the transthyretin-related cardiac amyloidosis from the light-chain cardiac amyloidosis. We report cases of a 73-year-old man and a 75-year-old woman followed in our center for congestive heart failure with marked alteration of the left ventricular ejection fraction due to familial transthyretin Val122Ile cardiac amyloidosis and light-chain cardiac amyloidosis, respectively, confirmed on endomyocardial biopsy.

Keywords: PET/CT; [18F]-NaF; cardiac amyloidosis; protein deposition.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amyloidosis / diagnostic imaging*
  • Cardiac Imaging Techniques / methods*
  • Diagnosis, Differential
  • Female
  • Fluorine Radioisotopes
  • Heart Diseases / diagnostic imaging*
  • Humans
  • Male
  • Positron Emission Tomography Computed Tomography / methods*
  • Radiopharmaceuticals
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Sodium Fluoride*

Substances

  • Fluorine Radioisotopes
  • Radiopharmaceuticals
  • Sodium Fluoride