Abstract
We used a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. The NME8 locus influenced PTK2B and the CD33 risk allele led to greater TREM2 expression. There was also a decreased TREM1/TREM2 ratio with a TREM1 risk allele, decreased TREM2 expression with CD33 suppression and elevated cortical TREM2 mRNA expression with amyloid pathology.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Alzheimer Disease / genetics
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Alzheimer Disease / metabolism*
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Amyloid / metabolism
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Genetic Predisposition to Disease*
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Humans
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Membrane Glycoproteins / genetics*
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Membrane Glycoproteins / metabolism*
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Microglia / metabolism
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Mutation / genetics*
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Receptors, Immunologic / biosynthesis
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Receptors, Immunologic / genetics*
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Receptors, Immunologic / metabolism*
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Sialic Acid Binding Ig-like Lectin 3 / metabolism*
Substances
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Amyloid
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CD33 protein, human
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Membrane Glycoproteins
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Receptors, Immunologic
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Sialic Acid Binding Ig-like Lectin 3
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TREM2 protein, human