Nutrition and the science of disease prevention: a systems approach to support metabolic health

Ann N Y Acad Sci. 2015 Sep:1352:1-12. doi: 10.1111/nyas.12945.

Abstract

Progress in nutritional science, genetics, computer science, and behavioral economics can be leveraged to address the challenge of noncommunicable disease. This report highlights the connection between nutrition and the complex science of preventing disease and discusses the promotion of optimal metabolic health, building on input from several complementary disciplines. The discussion focuses on (1) the basic science of optimal metabolic health, including data from gene-diet interactions, microbiome, and epidemiological research in nutrition, with the goal of defining better targets and interventions, and (2) how nutrition, from pharma to lifestyle, can build on systems science to address complex issues.

Keywords: body weight; diabetes; gene-diet interactions; gut microbiome; obesity; systems science.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Gene-Environment Interaction*
  • Humans
  • Life Style*
  • Metabolic Diseases* / epidemiology
  • Metabolic Diseases* / genetics
  • Metabolic Diseases* / metabolism
  • Metabolic Diseases* / prevention & control
  • Microbiota*
  • Nutritional Sciences / methods