Thermoresponsive release of viable microfiltrated Circulating Tumor Cells (CTCs) for precision medicine applications

Lab Chip. 2015 Nov 21;15(22):4277-82. doi: 10.1039/c5lc01024a.

Abstract

Stimulus responsive release of Circulating Tumor Cells (CTCs), with high recovery rates from their capture platform, is highly desirable for off-chip analyses. Here, we present a temperature responsive polymer coating method to achieve both release as well as culture of viable CTCs captured from patient blood samples.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acrylic Resins / chemistry
  • Cell Line, Tumor
  • Cell Survival
  • Humans
  • Microfluidic Analytical Techniques*
  • Neoplastic Cells, Circulating / pathology*
  • Polymers / chemistry
  • Precision Medicine*
  • Temperature*

Substances

  • Acrylic Resins
  • Polymers
  • poly-N-isopropylacrylamide